| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-1 |
|---|
| Ligand | BDBM50289399 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_90985 |
|---|
| Ki | 40±n/a nM |
|---|
| Citation |  Semple, G; Ashworth, DM; Baker, GR; Batt, AR; Baxter, AJ; Benzies, DW; Elliot, LH; Evans, D; Franklin, RJ; Hudson, P; Jenkins, PD; Pitt, GR; Rooker, DP; Sheppard, A; Szelke, M; Yamamoto, S; Isomura, Y PYRIDONE-BASED PEPTIDOMIMETIC INHIBITORS OF INTERLEUKIN-1β-CONVERTING ENZYME (ICE) Bioorg Med Chem Lett7:1337-1342 (1997) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Caspase-1 |
|---|
| Name: | Caspase-1 |
|---|
| Synonyms: | CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45154.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29466 |
|---|
| Residue: | 404 |
|---|
| Sequence: | MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
|
|
|
|---|
| BDBM50289399 |
|---|
| n/a |
|---|
| Name | BDBM50289399 |
|---|
| Synonyms: | (S)-3-(2-{6-Ethyl-3-[(naphthalene-1-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-acetylamino)-4-oxo-5-phenoxy-pentanoic acid | CHEMBL26302 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H29N3O7 |
|---|
| Mol. Mass. | 555.5779 |
|---|
| SMILES | CCc1ccc(NC(=O)c2cccc3ccccc23)c(=O)n1CC(=O)N[C@@H](CC(O)=O)C(=O)COc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
