| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50289720 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_105348 |
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| IC50 | 260±n/a nM |
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| Citation |  Yamada, Y; Ando, K; Komiyama, K; Shibata, S; Nakamura, I; Hayashi, Y; Ikegami, K; Uchida, I Novel low molecular renin inhibitors which show good oral blood pressure lowering effects in marmosets Bioorg Med Chem Lett7:1863-1868 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50289720 |
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| n/a |
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| Name | BDBM50289720 |
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| Synonyms: | 5-Chloro-1H-indole-2-carboxylic acid [(S)-1-((1S,2S,4S)-1-cyclohexylmethyl-2,4-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-amide | CHEMBL432889 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H40ClN5O4 |
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| Mol. Mass. | 558.112 |
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| SMILES | CC(C)[C@@H](O)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1cc2cc(Cl)ccc2[nH]1 |
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| Structure | 
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