| Reaction Details |
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 | Report a problem with these data |
| Target | Stromelysin-1 |
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| Ligand | BDBM50290085 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_205639 |
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| IC50 | 9.1±n/a nM |
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| Citation |  Broadhurst, MJ; Brown, PA; Lawton, G; Ballantyne, N; Borkakoti, N; Bottomley, KM; Cooper, MI; Eatherton, AJ; Kilford, IR; Malsher, PJ; Nixon, JS; Lewis, EJ; Sutton, BM; Johnson, WH Design and synthesis of the cartilage protective agent (CPA, Ro32-3555) Bioorg Med Chem Lett7:2299-2302 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stromelysin-1 |
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| Name: | Stromelysin-1 |
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| Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 53973.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08254 |
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| Residue: | 477 |
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| Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
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| BDBM50290085 |
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| n/a |
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| Name | BDBM50290085 |
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| Synonyms: | (2S,3R)-N*4*-((R)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-N*1*-hydroxy-3-isobutyl-succinamide | CHEMBL74670 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H34N4O6 |
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| Mol. Mass. | 474.55 |
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| SMILES | CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](CN1C(=O)c2ccccc2C1=O)C(=O)NO)C(C)(C)C |
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| Structure | 
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