Reaction Details | |||
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Target | Sigma non-opioid intracellular receptor 1 | ||
Ligand | BDBM50290091 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_201429 | ||
Ki | 4.3±n/a nM | ||
Citation | Yamashita, A; Takahashi, N; Mochizuki, D; Tsujita, R; Yamada, S; Kawakubo, H; Suzuki, Y; Watanabe, H An aromatic moiety is not essential for pharmacophore binding to sigma binding sites: Synthesis of N-alkylazacycloheptane derivatives as potent sigma ligands Bioorg Med Chem Lett7:2303-2306 (1997) Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sigma non-opioid intracellular receptor 1 | |||
Name: | Sigma non-opioid intracellular receptor 1 | ||
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 25124.85 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q99720 | ||
Residue: | 223 | ||
Sequence: |
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BDBM50290091 | |||
n/a | |||
Name | BDBM50290091 | ||
Synonyms: | (S)-3-(2-Adamantan-2-yl-ethyl)-1,8,8-trimethyl-3-aza-bicyclo[3.2.1]octane | CHEMBL73818 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H37N | ||
Mol. Mass. | 315.5359 | ||
SMILES | CC1(C)C2CC[C@]1(C)CN(CCC1C3CC4CC(C3)CC1C4)C2 |wD:6.7,TLB:11:12:14:17.18.16,THB:16:15:12:17.18.19,16:17:12:15.14.21,10:9:1:5.4,11:12:15.14.21:17.18.19,19:20:14:17.18.16,19:17:14:20.12.21,(-7.25,2.8,;-5.75,2.79,;-6.14,4.25,;-4.39,2.21,;-4,.76,;-4.93,-.34,;-4.93,1.16,;-6.43,1.16,;-2.69,2.13,;-1.35,1.44,;-.27,.4,;1.17,.82,;2.25,-.23,;2.88,-1.98,;2.25,-3.46,;3.36,-4.49,;5,-4.47,;5.66,-2.93,;4.41,-2.03,;5.18,-1.24,;3.56,-1.24,;2.87,-2.78,;-2.32,3.17,)| | ||
Structure |