| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prothrombin |
|---|
| Ligand | BDBM50081158 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_48295 |
|---|
| IC50 | 2.1±n/a nM |
|---|
| Citation |  Semple, JE; Minami, NK; Tamura, SY; Brunck, TK; Nutt, RF; Ripka, WC Rational design and synthesis of a novel, selective class of thrombin inhibitors: P1-argininal derivatives incorporating P3---P4 quaternary lactam dipeptide surrogates Bioorg Med Chem Lett7:2421-2426 (1997) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prothrombin |
|---|
| Name: | Prothrombin |
|---|
| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 70029.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00734 |
|---|
| Residue: | 622 |
|---|
| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
|
|
|
|---|
| BDBM50081158 |
|---|
| n/a |
|---|
| Name | BDBM50081158 |
|---|
| Synonyms: | 2-((R)-3-Amino-3-benzyl-2-oxo-piperidin-1-yl)-N-((S)-1-carbamimidoyl-2-hydroxy-piperidin-3-yl)-acetamide | CHEMBL314914 | CHEMBL79422 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H30N6O3 |
|---|
| Mol. Mass. | 402.4906 |
|---|
| SMILES | NC(=N)N1CCC[C@H](NC(=O)CN2CCC[C@@](N)(Cc3ccccc3)C2=O)C1O |
|---|
| Structure | 
|
|---|
Search and Browse
