| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50290307 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_144915 |
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| IC50 | 4±n/a nM |
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| Citation |  Burkholder, TP; Kudlacz, EM; Maynard, GD; Liu, XG; Le, TB; Webster, ME; Horgan, SW; Wenstrup, DL; Freund, DW; Boyer, F; Bratton, L; Gross, RS; Knippenberg, RW; Logan, DE; Jones, BK; Chen, TM; Geary, JL; Correll, MA; Poole, JC; Mandagere, AK Synthesis and structure-activity relationships for a series of substituted pyrrolidine NK1/NK2 receptor antagonists Bioorg Med Chem Lett7:2531-2536 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK1R_CAVPO | Neurokinin 1 receptor | Neurokinin NK1 | TAC1R | TACR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 46261.42 |
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| Organism: | GUINEA PIG |
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| Description: | Neurokinin NK1 TACR1 GUINEA PIG::P30547 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVC
MIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTIST
VVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
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| BDBM50290307 |
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| n/a |
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| Name | BDBM50290307 |
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| Synonyms: | 1'-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl}-2',3',5',6'-tetrahydro-1'H-[3,4']bipyridinyl-4'-carboxylic acid amide; hydrochloride | CHEMBL554092 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H38Cl2N4O5 |
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| Mol. Mass. | 641.585 |
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| SMILES | COc1cc(cc(OC)c1OC)C(=O)N1CC[C@@](CCN2CCC(CC2)(C(N)=O)c2cccnc2)(C1)c1ccc(Cl)c(Cl)c1 |r| |
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| Structure | 
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