| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50290461 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_142703 (CHEMBL744935) |
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| Ki | 9±n/a nM |
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| Citation |  Fauchère, JL; Kucharczyk, N; Jacoby, E; Lonchampt, M; Robineau, P; Dacquet, C; Regoli, D; Canet, E The dipeptide neurokinin-1 receptor antagonist S19752 is a potent and long-acting inhibitor of bronchoconstriction when administered by aerosol to the guinea pig in vivo Bioorg Med Chem Lett7:203-208 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50290461 |
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| n/a |
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| Name | BDBM50290461 |
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| Synonyms: | CHEMBL65468 | potassium 3,5-di(trifluoromethyl)benzyl 2-[4-hydroxy-1-{1-[4-(1H-1,2,3,4-tetraazol-5-yl)butyl]-1H-3-indolylcarbonyl}-(2R,4S)-tetrahydro-1H-2-pyrrolylcarboxamido]-3-(1H-3-indolyl)-(2S)-propanoate |
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| Type | Small organic molecule |
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| Emp. Form. | C39H35F6N8O5 |
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| Mol. Mass. | 809.7368 |
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| SMILES | OC1CC(N(C1)C(=O)c1cn(CCCCc2nn[n-]n2)c2ccccc12)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F |
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| Structure | 
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