| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neutrophil collagenase |
|---|
| Ligand | BDBM50291449 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_105206 (CHEMBL713845) |
|---|
| IC50 | 2600±n/a nM |
|---|
| Citation |  Baxter, AD; Bird, J; Bhogal, R; Massil, T; Minton, KJ; Montana, J; Owen, DA A novel series of matrix metalloproteinase inhibitors for the treatment of inflammatory disorders Bioorg Med Chem Lett7:897-902 (1997) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neutrophil collagenase |
|---|
| Name: | Neutrophil collagenase |
|---|
| Synonyms: | MMP8_RAT | Matrix metalloproteinase 8 | Mmp8 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 53278.33 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_12591 |
|---|
| Residue: | 466 |
|---|
| Sequence: | MLHLKTLPFLFFFHTQLATALPVPPEHLEEKNMKTAENYLRKFYHLPSNQFRSARNATMI
AEKLKEMQRFFGLPETGKPDAATIEIMEKPRCGVPDSGDFLLTPGSPKWTHTNLTYRIIN
HTPQMSKAEVKTEIEKAFKIWSVPSTLTFTETLEGEADINIAFVSRDHGDNSPFDGPNGI
LAHAFQPGRGIGGDAHFDSEETWTQDSKNYNLFLVAAHEFGHSLGLSHSTDPGALMYPNY
AYREPSTYSLPQDDINGIQTIYGPSDNPVQPTGPSTPTACDPHLRFDAATTLRGEIYFFK
DKYFWRRHPQLRTVDLNFISLFWPFLPNGLQAAYEDFDRDLVFLFKGRQYWALSAYDLQQ
GYPRDISNYGFPRSVQAIDAAVSYNGKTYFFVNNQCWRYDNQRRSMDPGYPTSIASVFPG
INCRIDAVFQQDSFFLFFSGPQYFAFNLVSRRVTRVARSNLWLNCP
|
|
|
|---|
| BDBM50291449 |
|---|
| n/a |
|---|
| Name | BDBM50291449 |
|---|
| Synonyms: | (S)-4-Methyl-2-(2-methylsulfanyl-acetylamino)-pentanoic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide | CHEMBL353472 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H29N3O3S |
|---|
| Mol. Mass. | 379.517 |
|---|
| SMILES | CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)CSC |
|---|
| Structure | 
|
|---|
Search and Browse
