| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50063719 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_64652 (CHEMBL674804) |
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| KOFF | 0.000018 s-1 |
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| Citation |  Krantz, A; Spencer, RW; Tam, TF; Thomas, E; Copp, LJ. Design of alternate substrate inhibitors of serine proteases. Synergistic use of alkyl substitution to impede enzyme-catalyzed deacylation. J Med Chem30:589-591 (1987) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50063719 |
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| n/a |
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| Name | BDBM50063719 |
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| Synonyms: | 2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-one | CHEMBL10756 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H14N2O2 |
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| Mol. Mass. | 218.2518 |
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| SMILES | CC(C)Nc1nc2cccc(C)c2c(=O)o1 |
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| Structure | 
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