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TargetNeutrophil elastase
LigandBDBM50291763
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63835 (CHEMBL872885)
Ki 4.2±n/a nM
Citation Krantz, ASpencer, RWTam, TFThomas, ECopp, LJ. Design of alternate substrate inhibitors of serine proteases. Synergistic use of alkyl substitution to impede enzyme-catalyzed deacylation. J Med Chem30:589-591 (1987) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50291763
n/a
NameBDBM50291763
Synonyms:2-Butylamino-5-ethyl-benzo[d][1,3]oxazin-4-one | CHEMBL143431
TypeSmall organic molecule
Emp. Form.C14H18N2O2
Mol. Mass.246.3049
SMILESCCCCNc1nc2cccc(CC)c2c(=O)o1
Structure
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