Reaction Details |
| Report a problem with these data |
Target | Squalene synthase |
---|
Ligand | BDBM50292415 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_484347 (CHEMBL999228) |
---|
IC50 | 0.2±n/a nM |
---|
Citation | Dufresne, C; Wilson, KE; Singh, SB; Zink, DL; Bergstrom, JD; Rew, D; Polishook, JD; Meinz, M; Huang, L; Silverman, KC; Lingham, RB; Mojena, M; Cascales, C; Pelaéz, F; Gibbs, JB Zaragozic Acids D and D2: Potent Inhibitors of Squalene Synthase and of Ras Farnesyl-Protein Transferase J Nat Prod56:1923-1929 (1993) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Squalene synthase |
---|
Name: | Squalene synthase |
Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase |
Type: | PROTEIN |
Mol. Mass.: | 48109.41 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1336736 |
Residue: | 416 |
Sequence: | MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
|
|
|
BDBM50292415 |
---|
n/a |
---|
Name | BDBM50292415 |
Synonyms: | CHEMBL504845 | Zaragozic Acid B |
Type | Small organic molecule |
Emp. Form. | C39H54O13 |
Mol. Mass. | 730.8383 |
SMILES | C\C=C\CCCC\C=C\CCCCC(=O)O[C@@H]1[C@@H](O)[C@]2(CCC(C)C(O)C(C)C\C=C\c3ccccc3)O[C@@]1(C(O)=O)[C@@](O)([C@H](O2)C(O)=O)C(O)=O |r| |
Structure |
|