Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase transforming protein Abl

Ligand

BDBM50292498

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_506213 (CHEMBL942402)

IC50

200000±n/a nM

Citation

Chang, CJ; Geahlen, RL Protein-Tyrosine Kinase Inhibition: Mechanism-Based Discovery of Antitumor Agents J Nat Prod55:1529-1560 (1992) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase transforming protein Abl

Name:

Tyrosine-protein kinase transforming protein Abl

Synonyms:

ABL | ABL_MLVAB | Tyrosine-protein kinase V-ABL

Type:

Enzyme

Mol. Mass.:

81895.89

Organism:

Abelson murine leukemia virus

Description:

P00521

Residue:

746

Sequence:

YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY
RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDK
WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK
HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYL
EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN
KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA
CWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPTKTRT
CRRAAEQKASPPSLTPKLLRRQVTASPSSGLSHKKEATKGSASGMGTPATAEPAPPSNKV
GLSKASSEEMRVRRHKHSSESPGRDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEA
GGPTKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPST
APAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAIS
RNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATA
SSGPAATQDFSKLLSSVKEISDIVRR

BDBM50292498

n/a

Name

BDBM50292498

Synonyms:

CHEMBL486679 | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}({[hydroxy({hydroxy[(4-methylphenyl)amino]phosphoryl}oxy)phosphoryl]oxy})phosphinic acid

Type

Small organic molecule

Emp. Form.

C17H23N6O12P3

Mol. Mass.

596.3188

SMILES

Cc1ccc(NP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)cc1 |r|

Structure