| Reaction Details |
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 | Report a problem with these data |
| Target | Ribonuclease pancreatic |
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| Ligand | BDBM50292721 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_493877 (CHEMBL944248) |
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| Ki | 41±n/a nM |
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| Citation |  Samanta, A; Leonidas, DD; Dasgupta, S; Pathak, T; Zographos, SE; Oikonomakos, NG Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: synthesis, biochemical, and crystallographic evaluation. J Med Chem52:932-42 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribonuclease pancreatic |
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| Name: | Ribonuclease pancreatic |
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| Synonyms: | CAM-RNase A | RNAS1_BOVIN | RNASE1 | RNAse A | RNS1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 16468.79 |
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| Organism: | Bison bison (American bison) |
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| Description: | carboxamidomethylated RNase A |
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| Residue: | 150 |
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| Sequence: | MALKSLVLLSLLVLVLLLVRVQPSLGKETAAAKFERQHMDSSTSAASSSNYCNQMMKSRN
LTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPN
CAYKTTQANKHIIVACEGNPYVPVHFDASV
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| BDBM50292721 |
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| n/a |
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| Name | BDBM50292721 |
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| Synonyms: | CHEMBL504858 | [({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy})phosphinic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C20H29N7O20P4 |
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| Mol. Mass. | 811.3742 |
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| SMILES | Cc1cn([C@H]2C[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3OP(O)(O)=O)n3cnc4c(N)ncnc34)[C@@H](COP(O)(O)=O)O2)c(=O)[nH]c1=O |
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| Structure | 
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