| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
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| Ligand | BDBM50208999 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_519456 (CHEMBL950882) |
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| IC50 | 1.5±n/a nM |
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| Citation |  Merritt, JR; Liu, J; Quadros, E; Morris, ML; Liu, R; Zhang, R; Jacob, B; Postelnek, J; Hicks, CM; Chen, W; Kimble, EF; Rogers, WL; O'Brien, L; White, N; Desai, H; Bansal, S; King, G; Ohlmeyer, MJ; Appell, KC; Webb, ML Novel pyrrolidine ureas as C-C chemokine receptor 1 (CCR1) antagonists. J Med Chem52:1295-301 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 1 |
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| Name: | C-C chemokine receptor type 1 |
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| Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41180.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32246 |
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| Residue: | 355 |
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| Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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| BDBM50208999 |
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| n/a |
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| Name | BDBM50208999 |
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| Synonyms: | (R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenyl)urea | (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea | BX-471 | BX-741 | CHEMBL232656 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24ClFN4O3 |
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| Mol. Mass. | 434.892 |
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| SMILES | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1NC(N)=O |r| |
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| Structure | 
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