| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Luciferin 4-monooxygenase |
|---|
| Ligand | BDBM50293110 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_514919 (CHEMBL972645) |
|---|
| IC50 | 860±n/a nM |
|---|
| Citation |  Auld, DS; Zhang, YQ; Southall, NT; Rai, G; Landsman, M; MacLure, J; Langevin, D; Thomas, CJ; Austin, CP; Inglese, J A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. J Med Chem52:1450-8 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Luciferin 4-monooxygenase |
|---|
| Name: | Luciferin 4-monooxygenase |
|---|
| Synonyms: | LUCI_PHOPE |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 60658.88 |
|---|
| Organism: | Photuris pennsylvanica |
|---|
| Description: | ChEMBL_514919 |
|---|
| Residue: | 545 |
|---|
| Sequence: | MEDKNILYGPEPFHPLADGTAGEQMFYALSRYADISGCIALTNAHTKENVLYEEFLKLSC
RLAESFKKYGLKQNDTIAVCSENGLQFFLPLIASLYLGIIAAPVSDKYIERELIHSLGIV
KPRIIFCSKNTFQKVLNVKSKLKYVETIIILDLNEDLGGYQCLNNFISQNSDINLDVKKF
KPNSFNRDDQVALVMFSSGTTGVSKGVMLTHKNIVARFSHCKDPTFGNAINPTTAILTVI
PFHHGFGMTTTLGYFTCGFRVALMHTFEEKLFLQSLQDYKVESTLLVPTLMAFFPKSALV
EKYDLSHLKEIASGGAPLSKEIGEMVKKRFKLNFVRQGYGLTETTSAVLITPDTDVRPGS
TGKIVPFHAVKVVDPTTGKILGPNETGELYFKGDMIMKSYYNNEEATKAIINKDGWLRSG
DIAYYDNDGHFYIVDRLKSLIKYKGYQVAPAEIEGILLQHPYIVDAGVTGIPDEAAGELP
AAGVVVQTGKYLNEQIVQNFVSSQVSTAKWLRGGVKFLDEIPKGSTGKIDRKVLRQMFEK
HKSKL
|
|
|
|---|
| BDBM50293110 |
|---|
| n/a |
|---|
| Name | BDBM50293110 |
|---|
| Synonyms: | 2-(4-Fluorophenyl)-6-methoxybenzo[d]thiazole | 6-Methoxy-2-(4'-fluorophenyl)-1,3-benzothiazole | CHEMBL490083 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H10FNOS |
|---|
| Mol. Mass. | 259.299 |
|---|
| SMILES | COc1ccc2nc(sc2c1)-c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
