| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Luciferin 4-monooxygenase |
|---|
| Ligand | BDBM50293115 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_514920 (CHEMBL972646) |
|---|
| IC50 | 3200±n/a nM |
|---|
| Citation |  Auld, DS; Zhang, YQ; Southall, NT; Rai, G; Landsman, M; MacLure, J; Langevin, D; Thomas, CJ; Austin, CP; Inglese, J A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. J Med Chem52:1450-8 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Luciferin 4-monooxygenase |
|---|
| Name: | Luciferin 4-monooxygenase |
|---|
| Synonyms: | LUCI_PHOPY | Luciferase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 60747.46 |
|---|
| Organism: | Photinus pyralis |
|---|
| Description: | ChEMBL_938513 |
|---|
| Residue: | 550 |
|---|
| Sequence: | MEDAKNIKKGPAPFYPLEDGTAGEQLHKAMKRYALVPGTIAFTDAHIEVNITYAEYFEMS
VRLAEAMKRYGLNTNHRIVVCSENSLQFFMPVLGALFIGVAVAPANDIYNERELLNSMNI
SQPTVVFVSKKGLQKILNVQKKLPIIQKIIIMDSKTDYQGFQSMYTFVTSHLPPGFNEYD
FVPESFDRDKTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDPIFGNQIIPDTAILSV
VPFHHGFGMFTTLGYLICGFRVVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFFAKSTL
IDKYDLSNLHEIASGGAPLSKEVGEAVAKRFHLPGIRQGYGLTETTSAILITPEGDDKPG
AVGKVVPFFEAKVVDLDTGKTLGVNQRGELCVRGPMIMSGYVNNPEATNALIDKDGWLHS
GDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELESILLQHPNIFDAGVAGLPDDDAGEL
PAAVVVLEHGKTMTEKEIVDYVASQVTTAKKLRGGVVFVDEVPKGLTGKLDARKIREILI
KAKKGGKSKL
|
|
|
|---|
| BDBM50293115 |
|---|
| n/a |
|---|
| Name | BDBM50293115 |
|---|
| Synonyms: | 2-(3,4-Dimethoxyphenyl)benzo[d]thiazol | 2-(3,4-dimethoxyphenyl)benzothiazole | CHEMBL201610 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H13NO2S |
|---|
| Mol. Mass. | 271.334 |
|---|
| SMILES | COc1ccc(cc1OC)-c1nc2ccccc2s1 |
|---|
| Structure | 
|
|---|
Search and Browse
