| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 7 |
|---|
| Ligand | BDBM5931 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_496974 (CHEMBL1004615) |
|---|
| IC50 | 62±n/a nM |
|---|
| Citation |  Choong, IC; Serafimova, I; Fan, J; Stockett, D; Chan, E; Cheeti, S; Lu, Y; Fahr, B; Pham, P; Arkin, MR; Walker, DH; Hoch, U A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties. Bioorg Med Chem Lett18:5763-5 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 7 |
|---|
| Name: | Cyclin-dependent kinase 7 |
|---|
| Synonyms: | 39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 39047.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 346 |
|---|
| Sequence: | MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
|
|
|
|---|
| BDBM5931 |
|---|
| n/a |
|---|
| Name | BDBM5931 |
|---|
| Synonyms: | BMS-387072 | CHEMBL296468 | N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide | N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide | cid_3025986 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H24N4O2S2 |
|---|
| Mol. Mass. | 380.528 |
|---|
| SMILES | CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 |
|---|
| Structure | 
|
|---|
Search and Browse
