Reaction Details | |||
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Target | Cyclin-dependent kinase 7 | ||
Ligand | BDBM50293174 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_496974 (CHEMBL1004615) | ||
IC50 | 105±n/a nM | ||
Citation | Choong, IC; Serafimova, I; Fan, J; Stockett, D; Chan, E; Cheeti, S; Lu, Y; Fahr, B; Pham, P; Arkin, MR; Walker, DH; Hoch, U A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties. Bioorg Med Chem Lett18:5763-5 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Cyclin-dependent kinase 7 | |||
Name: | Cyclin-dependent kinase 7 | ||
Synonyms: | 39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 39047.01 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 346 | ||
Sequence: |
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BDBM50293174 | |||
n/a | |||
Name | BDBM50293174 | ||
Synonyms: | (trans)-N1-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)cyclohexane-1,4-diamine | CHEMBL496567 | ||
Type | Small organic molecule | ||
Emp. Form. | C17H26N4OS2 | ||
Mol. Mass. | 366.545 | ||
SMILES | CC(C)(C)c1cnc(CSc2cnc(N[C@H]3CC[C@H](N)CC3)s2)o1 |r,wU:18.18,wD:15.14,(8.72,-8.28,;10.22,-8.69,;10.66,-7.21,;9.78,-10.17,;11.68,-9.16,;12.15,-10.63,;13.7,-10.63,;14.18,-9.16,;15.64,-8.69,;16.79,-9.72,;18.25,-9.25,;19.5,-10.16,;20.74,-9.25,;20.27,-7.78,;21.18,-6.54,;22.71,-6.53,;23.48,-7.86,;25.01,-7.86,;25.78,-6.53,;27.32,-6.53,;25.01,-5.2,;23.47,-5.2,;18.73,-7.78,;12.93,-8.25,)| | ||
Structure |