| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50293199 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_497215 (CHEMBL1003672) |
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| Ki | 2.2±n/a nM |
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| Citation |  Letavic, MA; Keith, JM; Ly, KS; Bonaventure, P; Feinstein, MA; Lord, B; Miller, KL; Motley, ST; Nepomuceno, D; Sutton, SW; Carruthers, NI 2-Aryloxymethylmorpholine histamine H(3) antagonists. Bioorg Med Chem Lett18:5796-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50293199 |
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| n/a |
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| Name | BDBM50293199 |
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| Synonyms: | 4-cyclopentyl-2-((4-(pyrrolidin-1-ylmethyl)phenoxy)methyl)morpholine | CHEMBL496167 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H32N2O2 |
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| Mol. Mass. | 344.491 |
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| SMILES | C(Oc1ccc(CN2CCCC2)cc1)C1CN(CCO1)C1CCCC1 |
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| Structure | 
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