Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM50293234 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_497219 (CHEMBL1006172) |
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IC50 | 6±n/a nM |
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Citation | Aissaoui, H; Koberstein, R; Zumbrunn, C; Gatfield, J; Brisbare-Roch, C; Jenck, F; Treiber, A; Boss, C N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists. Bioorg Med Chem Lett18:5729-33 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM50293234 |
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n/a |
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Name | BDBM50293234 |
Synonyms: | 2-(N-(2-chloro-5-(dimethylamino)phenyl)-3,4-dimethoxyphenylsulfonamido)-N-(1,5-dimethyl-1H-pyrazol-3-yl)-N-ethylacetamide | CHEMBL496979 |
Type | Small organic molecule |
Emp. Form. | C25H32ClN5O5S |
Mol. Mass. | 550.07 |
SMILES | CCN(C(=O)CN(c1cc(ccc1Cl)N(C)C)S(=O)(=O)c1ccc(OC)c(OC)c1)c1cc(C)n(C)n1 |
Structure |
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