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TargetGamma-aminobutyric acid receptor subunit alpha-3
LigandBDBM50293263
Substrate/Competitorn/a
Meas. Tech.ChEMBL_492500 (CHEMBL950413)
Ki 11±n/a nM
Citation Nilsson, JNielsen, EŘLiljefors, TNielsen, MSterner, O Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors. Bioorg Med Chem Lett18:5713-6 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Gamma-aminobutyric acid receptor subunit alpha-3
Name:Gamma-aminobutyric acid receptor subunit alpha-3
Synonyms:GABA A anti-Alpha3 | GABA A receptor alpha-3/beta-2/gamma-2 | GABA receptor alpha-3 subunit | GBRA3_RAT | Gabra-3 | Gabra3 | Gamma-aminobutyric acid receptor subunit alpha-3
Type:Enzyme Catalytic Domain
Mol. Mass.:55444.88
Organism:RAT
Description:GABA A Alpha3Beta2Gamma2 0 RAT::P20236
Residue:493
Sequence:
MITTQMWHFYVTRVGLLLLISILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDS
TDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQ
TWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLL
YTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDGSRL
NQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN
RESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFMAVCYAFVFSALIEFATVN
YFTKRSWAWEGKKVPEALEMKKKTPAAPTKKTSTTFNIVGTTYPINLALDTEFSTISKAA
AAPSASSTPTVIASPKTTYVQDSPAETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYV
NRESAIKGMIRKQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50293263
n/a
NameBDBM50293263
Synonyms:2-(5-benzyl-2-hydroxyphenyl)-6-methyl-4H-chromen-4-one | CHEMBL522061
TypeSmall organic molecule
Emp. Form.C23H18O3
Mol. Mass.342.3872
SMILESCc1ccc2oc(cc(=O)c2c1)-c1cc(Cc2ccccc2)ccc1O
Structure
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