| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 2 |
|---|
| Ligand | BDBM50293357 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_571846 (CHEMBL1034714) |
|---|
| IC50 | 460±n/a nM |
|---|
| Citation |  Dallavalle, S; Cincinelli, R; Nannei, R; Merlini, L; Morini, G; Penco, S; Pisano, C; Vesci, L; Barbarino, M; Zuco, V; De Cesare, M; Zunino, F Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. Eur J Med Chem44:1900-12 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 2 |
|---|
| Name: | Histone deacetylase 2 |
|---|
| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 55356.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q92769 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
|
|
|
|---|
| BDBM50293357 |
|---|
| n/a |
|---|
| Name | BDBM50293357 |
|---|
| Synonyms: | CHEMBL565140 | N-Hydroxy-E-3-[3'-chloro-4'-hydroxybiphenyl-4-yl]-acrylamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H12ClNO3 |
|---|
| Mol. Mass. | 289.714 |
|---|
| SMILES | ONC(=O)\C=C\c1ccc(cc1)-c1ccc(O)c(Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
