| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor X |
|---|
| Ligand | BDBM50293385 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_572141 (CHEMBL1027710) |
|---|
| IC50 | 2790±n/a nM |
|---|
| Citation |  Ayral, E; Gloanec, P; Bergé, G; de Nanteuil, G; Mennecier, P; Rupin, A; Verbeuren, TJ; Fulcrand, P; Martinez, J; Hernandez, JF Design, synthesis, and biological evaluation of 1,5-benzothiazepine-4-one derivatives targeting factor VIIa/tissue factor. Bioorg Med Chem Lett19:1386-91 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor X |
|---|
| Name: | Coagulation factor X |
|---|
| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54726.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
|---|
| BDBM50293385 |
|---|
| n/a |
|---|
| Name | BDBM50293385 |
|---|
| Synonyms: | 2-[(3S)-7-[2-Aminoethyl]-3-[benzylsulfonylamino]-4-oxo-3,4-dihydro-1,5-benzothiazepin-5(2H)-yl]-N-{4-[amino(imino)methyl]benzyl}-acetamide, bistrifluoroacetate | CHEMBL538929 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H32N6O4S2 |
|---|
| Mol. Mass. | 580.721 |
|---|
| SMILES | NCCc1ccc2SC[C@@H](NS(=O)(=O)Cc3ccccc3)C(=O)N(CC(=O)NCc3ccc(cc3)C(N)=N)c2c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
