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TargetSodium- and chloride-dependent glycine transporter 1
LigandBDBM50293562
Substrate/Competitorn/a
Meas. Tech.ChEMBL_570823 (CHEMBL792716)
Ki 4.6±n/a nM
Citation Lowe, JAHou, XSchmidt, CDavid Tingley, FMcHardy, SKalman, MDeninno, SSanner, MWard, KLebel, LTunucci, DValentine, JBronk, BSSchaeffer, E The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter. Bioorg Med Chem Lett19:2974-6 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium- and chloride-dependent glycine transporter 1
Name:Sodium- and chloride-dependent glycine transporter 1
Synonyms:GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9
Type:Enzyme
Mol. Mass.:78270.54
Organism:Homo sapiens (Human)
Description:P48067
Residue:706
Sequence:
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50293562
n/a
NameBDBM50293562
Synonyms:1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide | CHEMBL551424
TypeSmall organic molecule
Emp. Form.C20H25ClN4O
Mol. Mass.372.892
SMILESCCN1C[C@H]2[C@H](CN(Cc3cccc(Cl)c3)C(=O)c3cn(C)cn3)[C@H]2C1 |r|
Structure
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