| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 4 |
|---|
| Ligand | BDBM50263669 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_571886 (CHEMBL1034756) |
|---|
| EC50 | >5000±n/a nM |
|---|
| Citation |  Engers, DW; Niswender, CM; Weaver, CD; Jadhav, S; Menon, UN; Zamorano, R; Conn, PJ; Lindsley, CW; Hopkins, CR Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J Med Chem52:4115-8 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 4 |
|---|
| Name: | Metabotropic glutamate receptor 4 |
|---|
| Synonyms: | GPRC1D | GRM4 | GRM4_HUMAN | Glutamate receptor, metabotropic 4 | MGLUR4 | Metabotropic glutamate receptor 4 | Metabotropic glutamate receptor 4 (mGlu4) | Metabotropic glutamate receptor 4 (mGluR4) | metabotropic glutamate 4 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 101899.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q14833 |
|---|
| Residue: | 912 |
|---|
| Sequence: | MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR
GSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL
TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA
STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQ
KSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRA
NQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI
WFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL
HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY
QLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCW
HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIA
ATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG
LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVV
DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET
FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP
KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALAT
KQTYVTYTNHAI
|
|
|
|---|
| BDBM50263669 |
|---|
| n/a |
|---|
| Name | BDBM50263669 |
|---|
| Synonyms: | (1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetrahydrocyclopropa[b]chromene-1a-carboxamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14N2O3 |
|---|
| Mol. Mass. | 294.3047 |
|---|
| SMILES | O=NC1[C@@H]2C[C@@]2(Oc2ccccc12)C(=O)Nc1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
