Ki Summary

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Target

Kinesin-like protein KIF3B

Ligand

BDBM50293750

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_571922 (CHEMBL1035571)

IC50

>50000±n/a nM

Citation

Lahue, BR; Ma, Y; Shipps, GW; Seghezzi, W; Herbst, R Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors. Bioorg Med Chem Lett19:3405-9 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Kinesin-like protein KIF3B

Name:

Kinesin-like protein KIF3B

Synonyms:

KIAA0359 | KIF3B | KIF3B_HUMAN

Type:

PROTEIN

Mol. Mass.:

85132.22

Organism:

Homo sapiens (Human)

Description:

ChEMBL_571922

Residue:

747

Sequence:

MSKLKSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMPKTFTFD
AVYDWNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIP
NSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLS
SFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGK
LNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRL
LQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQE
EIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEK
LEIEKRAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKN
IVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETYSSLQQEVDIKTKK
LKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLIIENFIPLEEKSKIM
NRAFFDEEEDHWKLHPITRLENQQMMKRPVSAVGYKRPLSQHARMSMMIRPEARYRAENI
VLLELDMPSRTTRDYEGPAIAPKVQAALDAALQDEDEIQVDASSFESTANKKSKARPKSG
RKSGSSSSSSGTPASQLYPQSRGLVPK

BDBM50293750

n/a

Name

BDBM50293750

Synonyms:

1-(benzo[d]thiazol-2-ylmethyl)-2-(4-sulfamoylphenylamino)-1H-benzo[d]imidazole-5-carboxamide | CHEMBL559508

Type

Small organic molecule

Emp. Form.

C22H18N6O3S2

Mol. Mass.

478.547

SMILES

NC(=O)c1ccc2n(Cc3nc4ccccc4s3)c(Nc3ccc(cc3)S(N)(=O)=O)nc2c1

Structure