| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin heavy chain isoform 5A |
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| Ligand | BDBM50293751 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_571923 (CHEMBL1035572) |
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| IC50 | >50000±n/a nM |
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| Citation |  Lahue, BR; Ma, Y; Shipps, GW; Seghezzi, W; Herbst, R Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors. Bioorg Med Chem Lett19:3405-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kinesin heavy chain isoform 5A |
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| Name: | Kinesin heavy chain isoform 5A |
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| Synonyms: | KIF5A | KIF5A_HUMAN | NKHC1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 117363.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_818702 |
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| Residue: | 1032 |
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| Sequence: | MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVIGGKPYVFDRVFPPNTTQE
QVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHI
YSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEI
LDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVS
KTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTM
FICCSPSSYNDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETI
AKLEAELSRWRNGENVPETERLAGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYEEE
IRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAA
KDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVS
GHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKS
VVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQSVELKKRHLEES
YDSLSDELAKLQAQETVHEVALKDKEPDTQDADEVKKALELQMESHREAHHRQLARLRDE
INEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEEHEKSTKLQELTFLYERHEQSKQDL
KGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQL
TKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRI
KEAVRYKSSGKRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNSLFQNYQNLYLQ
ATPSSTSDMYFANSCTSSGATSSGGPLASYQKANMDNGNATDINDNRSDLPCGYEAEDQA
KLFPLHQETAAS
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| BDBM50293751 |
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| n/a |
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| Name | BDBM50293751 |
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| Synonyms: | 1-((5-chlorobenzo[b]thiophen-3-yl)methyl)-2-(4-sulfamoylphenylamino)-1H-benzo[d]imidazole-5-carboxamide | CHEMBL561294 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18ClN5O3S2 |
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| Mol. Mass. | 512.004 |
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| SMILES | NC(=O)c1ccc2n(Cc3csc4ccc(Cl)cc34)c(Nc3ccc(cc3)S(N)(=O)=O)nc2c1 |
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| Structure | 
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