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TargetHypoxanthine-guanine phosphoribosyltransferase
LigandBDBM50293829
Substrate/Competitorn/a
Meas. Tech.ChEMBL_572371 (CHEMBL1035272)
pH7.4±n/a
Ki>1000000±n/a nM
Commentsextracted
Citation Keough, DTHocková, DHolý, ANaesens, LMSkinner-Adams, TSJersey, JGuddat, LW Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. J Med Chem52:4391-9 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hypoxanthine-guanine phosphoribosyltransferase
Name:Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:Protein
Mol. Mass.:24579.61
Organism:Homo sapiens (Human)
Description:P00492
Residue:218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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  Blast E-value cutoff:
BDBM50293829
n/a
NameBDBM50293829
Synonyms:6-methylheptyl(2-(2-amino-6-oxo-1,6,7,8-tetrahydropurin-9-yl)ethoxy)methylphosphonate | CHEMBL561352
TypeSmall organic molecule
Emp. Form.C16H30N5O5P
Mol. Mass.403.4137
SMILESCC(C)CCCCCOP(O)(=O)COCCN1CNc2c1nc(N)[nH]c2=O
Structure
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