| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxanthine-guanine phosphoribosyltransferase |
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| Ligand | BDBM50293832 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_572371 (CHEMBL1035272) |
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| pH | 7.4±n/a |
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| Ki | >300000±n/a nM |
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| Comments | extracted |
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| Citation |  Keough, DT; Hocková, D; Holý, A; Naesens, LM; Skinner-Adams, TS; Jersey, J; Guddat, LW Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. J Med Chem52:4391-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hypoxanthine-guanine phosphoribosyltransferase |
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| Name: | Hypoxanthine-guanine phosphoribosyltransferase |
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| Synonyms: | HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
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| Type: | Protein |
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| Mol. Mass.: | 24579.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00492 |
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| Residue: | 218 |
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| Sequence: | MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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| BDBM50293832 |
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| n/a |
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| Name | BDBM50293832 |
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| Synonyms: | ((S)-1-(2-amino-8-bromo-6-oxo-1,6,7,8-tetrahydropurin-9-yl)propan-2-yloxy)methylphosphonate | CHEMBL555285 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H15BrN5O5P |
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| Mol. Mass. | 384.124 |
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| SMILES | C[C@@H](CN1C(Br)Nc2c1nc(N)[nH]c2=O)OCP(O)(O)=O |r| |
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| Structure | 
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