Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetProstaglandin E synthase
LigandBDBM50294199
Substrate/Competitorn/a
Meas. Tech.ChEMBL_571973 (CHEMBL1036476)
IC50 6200±n/a nM
Citation Liedtke, AJKeck, PRLehmann, FKoeberle, AWerz, OLaufer, SA Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX). J Med Chem52:4968-72 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E synthase
Name:Prostaglandin E synthase
Synonyms:MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:Protein
Mol. Mass.:17112.22
Organism:Homo sapiens (Human)
Description:n/a
Residue:152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50294199
n/a
NameBDBM50294199
Synonyms:2-(6-(benzofuran-6-yl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetic acid | CHEMBL561824
TypeSmall organic molecule
Emp. Form.C25H23NO3
Mol. Mass.385.455
SMILESCC1(C)Cc2c(c(c(CC(O)=O)n2C1)-c1ccc2ccoc2c1)-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: