Reaction Details |
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Target | Prostaglandin E synthase |
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Ligand | BDBM50294199 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_571973 (CHEMBL1036476) |
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IC50 | 6200±n/a nM |
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Citation | Liedtke, AJ; Keck, PR; Lehmann, F; Koeberle, A; Werz, O; Laufer, SA Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX). J Med Chem52:4968-72 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin E synthase |
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Name: | Prostaglandin E synthase |
Synonyms: | MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1) |
Type: | Protein |
Mol. Mass.: | 17112.22 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 152 |
Sequence: | MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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BDBM50294199 |
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n/a |
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Name | BDBM50294199 |
Synonyms: | 2-(6-(benzofuran-6-yl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetic acid | CHEMBL561824 |
Type | Small organic molecule |
Emp. Form. | C25H23NO3 |
Mol. Mass. | 385.455 |
SMILES | CC1(C)Cc2c(c(c(CC(O)=O)n2C1)-c1ccc2ccoc2c1)-c1ccccc1 |
Structure |
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