| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50294213 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_577084 (CHEMBL1031974) |
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| IC50 | >24000±n/a nM |
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| Citation |  Barrow, EW; Dreier, J; Reinelt, S; Bourne, PC; Barrow, WW In vitro efficacy of new antifolates against trimethoprim-resistant Bacillus anthracis. Antimicrob Agents Chemother51:4447-52 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50294213 |
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| n/a |
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| Name | BDBM50294213 |
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| Synonyms: | 3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2-hydroxy-3-methoxyphenyl)-1-(1-(4-(hydroxymethyl)phenyl)phthalazin-2(1H)-yl)prop-2-en-1-one | CHEMBL559830 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H28N6O4 |
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| Mol. Mass. | 536.5811 |
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| SMILES | COc1cc(Cc2cnc(N)nc2N)cc(\C=C\C(=O)N2N=Cc3ccccc3C2c2ccc(CO)cc2)c1O |c:22| |
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| Structure | 
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