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TargetDihydrofolate reductase
LigandBDBM50294217
Substrate/Competitorn/a
Meas. Tech.ChEMBL_577084 (CHEMBL1031974)
IC50>28000±n/a nM
Citation Barrow, EWDreier, JReinelt, SBourne, PCBarrow, WW In vitro efficacy of new antifolates against trimethoprim-resistant Bacillus anthracis. Antimicrob Agents Chemother51:4447-52 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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  Blast E-value cutoff:
BDBM50294217
n/a
NameBDBM50294217
Synonyms:3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)-1-(1-methylphthalazin-2(1H)-yl)propan-1-one | CHEMBL564880
TypeSmall organic molecule
Emp. Form.C25H28N6O3
Mol. Mass.460.5282
SMILESCOc1cc(Cc2cnc(N)nc2N)cc(CCC(=O)N2N=Cc3ccccc3C2C)c1OC |c:22|
Structure
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