| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 4E |
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| Ligand | BDBM50294222 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_574909 (CHEMBL1023606) |
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| IC50 | 8000±n/a nM |
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| Citation |  Kowalska, J; Lukaszewicz, M; Zuberek, J; Ziemniak, M; Darzynkiewicz, E; Jemielity, J Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation. Bioorg Med Chem Lett19:1921-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic translation initiation factor 4E |
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| Name: | Eukaryotic translation initiation factor 4E |
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| Synonyms: | EIF4E | IF4E_RABIT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 25047.40 |
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| Organism: | Oryctolagus cuniculus |
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| Description: | ChEMBL_1511842 |
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| Residue: | 217 |
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| Sequence: | MATVEPETTPTPNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
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| BDBM50294222 |
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| n/a |
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| Name | BDBM50294222 |
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| Synonyms: | ((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxido-9H-purin-1-ium-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate | CHEMBL550695 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H14N5O14P3 |
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| Mol. Mass. | 533.1774 |
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| SMILES | C[n+]1cn(C2OC(COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12 |
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| Structure | 
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