Reaction Details |
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Target | Hexokinase-4 |
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Ligand | BDBM50294470 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_575546 (CHEMBL1035543) |
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EC50 | 38±n/a nM |
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Citation | Mitsuya, M; Kamata, K; Bamba, M; Watanabe, H; Sasaki, Y; Sasaki, K; Ohyama, S; Hosaka, H; Nagata, Y; Eiki, J; Nishimura, T Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators. Bioorg Med Chem Lett19:2718-21 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hexokinase-4 |
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Name: | Hexokinase-4 |
Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
Type: | Enzyme |
Mol. Mass.: | 52175.81 |
Organism: | Homo sapiens (Human) |
Description: | P35557 |
Residue: | 465 |
Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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BDBM50294470 |
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n/a |
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Name | BDBM50294470 |
Synonyms: | 6-(4H-1,2,4-triazol-3-ylthio)-3-(phenylthio)-N-(thiazol-2-yl)picolinamide | CHEMBL551648 |
Type | Small organic molecule |
Emp. Form. | C17H12N6OS3 |
Mol. Mass. | 412.512 |
SMILES | O=C(Nc1nccs1)c1nc(Sc2nnc[nH]2)ccc1Sc1ccccc1 |
Structure |
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