| Reaction Details |
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 | Report a problem with these data |
| Target | Prokineticin receptor 1 |
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| Ligand | BDBM50294586 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_575799 (CHEMBL1057723) |
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| IC50 | 22±n/a nM |
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| Citation |  Ralbovsky, JL; Lisko, JG; Palmer, JM; Mabus, J; Chevalier, KM; Schulz, MJ; Dyatkin, AB; Miskowski, TA; Coats, SJ; Hornby, P; He, W Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR, synthesis and biological evaluation. Bioorg Med Chem Lett19:2661-3 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prokineticin receptor 1 |
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| Name: | Prokineticin receptor 1 |
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| Synonyms: | G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1 |
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| Type: | enzyme |
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| Mol. Mass.: | 44779.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8TCW9 |
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| Residue: | 393 |
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| Sequence: | METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFA
AKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEM
DYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTAT
GLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIE
FVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPF
YGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLH
WKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
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| BDBM50294586 |
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| n/a |
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| Name | BDBM50294586 |
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| Synonyms: | 1-(2-(5-(3,4-dichlorobenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine | CHEMBL550780 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23Cl2N7O3 |
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| Mol. Mass. | 492.358 |
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| SMILES | [#6]-[#8]-c1ccc(-[#6]-n2c(-[#7]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])nc(=O)n(-[#6]-c3ccc(Cl)c(Cl)c3)c2=O)cc1 |
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| Structure | 
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