Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Prokineticin receptor 1 | ||
| Ligand | BDBM50294600 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_575799 (CHEMBL1057723) | ||
| IC50 | 3260±n/a nM | ||
| Citation |  Ralbovsky, JL; Lisko, JG; Palmer, JM; Mabus, J; Chevalier, KM; Schulz, MJ; Dyatkin, AB; Miskowski, TA; Coats, SJ; Hornby, P; He, W Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR, synthesis and biological evaluation. Bioorg Med Chem Lett19:2661-3 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Prokineticin receptor 1 | |||
| Name: | Prokineticin receptor 1 | ||
| Synonyms: | G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1 | ||
| Type: | enzyme | ||
| Mol. Mass.: | 44779.92 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q8TCW9 | ||
| Residue: | 393 | ||
| Sequence: |
| ||
| BDBM50294600 | |||
| n/a | |||
| Name | BDBM50294600 | ||
| Synonyms: | 1-(2-(5-(4-methoxybenzyl)-1-((4-methoxycyclohexyl)methyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine | CHEMBL550034 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H33N7O4 | ||
| Mol. Mass. | 459.5419 | ||
| SMILES | COC1CCC(Cn2c(NCCN=C(N)N)nc(=O)n(Cc3ccc(OC)cc3)c2=O)CC1 |(6.7,-34.55,;8.03,-35.32,;9.37,-34.56,;9.37,-33.02,;10.7,-32.25,;12.03,-33.03,;13.43,-32.12,;13.43,-30.58,;14.77,-29.81,;16.1,-30.58,;17.44,-29.8,;18.77,-30.57,;20.1,-29.8,;21.44,-30.57,;22.77,-29.8,;21.44,-32.11,;14.76,-28.26,;13.43,-27.49,;13.42,-25.95,;12.1,-28.26,;10.77,-27.49,;10.77,-25.95,;12.1,-25.19,;12.1,-23.65,;10.77,-22.88,;10.77,-21.34,;12.1,-20.57,;9.43,-23.66,;9.44,-25.19,;12.1,-29.81,;10.76,-30.58,;12.04,-34.57,;10.7,-35.33,)| | ||
| Structure | 
| ||