| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2C19 |
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| Ligand | BDBM50294701 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_576008 (CHEMBL1023634) |
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| IC50 | 91±n/a nM |
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| Citation |  Hammond, M; Patterson, JR; Manns, S; Hoang, TH; Washburn, DG; Trizna, W; Glace, L; Grygielko, ET; Nagilla, R; Nord, M; Fries, HE; Minick, DJ; Laping, NJ; Bray, JD; Thompson, SK Synthesis and SAR of amino acid-derived heterocyclic progesterone receptor full and partial agonists. Bioorg Med Chem Lett19:2637-41 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2C19 |
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| Name: | Cytochrome P450 2C19 |
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| Synonyms: | CP2CJ_HUMAN | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Cytochrome P450 2C19 [I331V] | Mephenytoin 4-hydroxylase | P450-11A | P450-254C |
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| Type: | Enzyme |
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| Mol. Mass.: | 55935.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P33261 |
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| Residue: | 490 |
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| Sequence: | MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV
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| BDBM50294701 |
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| n/a |
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| Name | BDBM50294701 |
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| Synonyms: | 4-((2-chlorobenzyl)(1-(5-methyl-1,3,4-oxadiazol-2-yl)ethyl)amino)-2-chlorobenzonitrile | CHEMBL559581 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16Cl2N4O |
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| Mol. Mass. | 387.263 |
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| SMILES | CC(N(Cc1ccccc1Cl)c1ccc(C#N)c(Cl)c1)c1nnc(C)o1 |
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| Structure | 
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