Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50295062 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_574192 (CHEMBL1060393) |
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Ki | 7.2±n/a nM |
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Citation | Zhou, D; Stack, GP; Lo, J; Failli, AA; Evrard, DA; Harrison, BL; Hatzenbuhler, NT; Tran, M; Croce, S; Yi, S; Golembieski, J; Hornby, GA; Lai, M; Lin, Q; Schechter, LE; Smith, DL; Shilling, AD; Huselton, C; Mitchell, P; Beyer, CE; Andree, TH Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists. J Med Chem52:4955-9 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A |
Type: | n/a |
Mol. Mass.: | 46122.49 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 422 |
Sequence: | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
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BDBM50295062 |
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n/a |
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Name | BDBM50295062 |
Synonyms: | 2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}piperazin-1-yl)quino-line-6-carboxamide | CHEMBL559778 |
Type | Small organic molecule |
Emp. Form. | C27H27N5O3 |
Mol. Mass. | 469.535 |
SMILES | Cc1ccc2c3O[C@@H](CN4CCN(CC4)c4ccc5cc(ccc5n4)C(N)=O)COc3ccc2n1 |r| |
Structure |
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