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TargetNeuromedin-B receptor
LigandBDBM50295227
Substrate/Competitorn/a
Meas. Tech.ChEMBL_577514 (CHEMBL1057866)
IC50 2000±n/a nM
Citation Fu, JShuttleworth, SJConnors, RVChai, ACoward, P Discovery and optimization of a novel Neuromedin B receptor antagonist. Bioorg Med Chem Lett19:4264-7 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuromedin-B receptor
Name:Neuromedin-B receptor
Synonyms:Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:43447.11
Organism:Homo sapiens (Human)
Description:Bombesin 1 NMBR 0::P28336
Residue:390
Sequence:
MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLG
NIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIP
VIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAV
FSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLI
KSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSL
GHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAV
RMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
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  Blast E-value cutoff:
BDBM50295227
n/a
NameBDBM50295227
Synonyms:11-(2-chloro-6-fluorophenyl)-3-(4-methoxyphenyl)-8-methyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one | CHEMBL552257
TypeSmall organic molecule
Emp. Form.C27H24ClFN2O2
Mol. Mass.462.943
SMILESCOc1ccc(cc1)C1CC(=O)C2C(Nc3cc(C)ccc3N=C2C1)c1c(F)cccc1Cl |c:24|
Structure
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