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TargetNeuromedin-B receptor
LigandBDBM50295235
Substrate/Competitorn/a
Meas. Tech.ChEMBL_577514 (CHEMBL1057866)
IC50 640±n/a nM
Citation Fu, JShuttleworth, SJConnors, RVChai, ACoward, P Discovery and optimization of a novel Neuromedin B receptor antagonist. Bioorg Med Chem Lett19:4264-7 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuromedin-B receptor
Name:Neuromedin-B receptor
Synonyms:Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:43447.11
Organism:Homo sapiens (Human)
Description:Bombesin 1 NMBR 0::P28336
Residue:390
Sequence:
MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLG
NIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIP
VIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAV
FSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLI
KSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSL
GHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAV
RMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
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  Blast E-value cutoff:
BDBM50295235
n/a
NameBDBM50295235
Synonyms:8'-methyl-11'-(2-(trifluoromethylthio)phenyl)-4',5',10',11'-tetrahydrospiro[cyclopentane-1,3'-dibenzo[b,e][1,4]diazepin]-1'(2'H)-one | CHEMBL557707
TypeSmall organic molecule
Emp. Form.C25H25F3N2OS
Mol. Mass.458.539
SMILESCc1ccc2N=C3CC4(CCCC4)CC(=O)C3C(Nc2c1)c1ccccc1SC(F)(F)F |t:5|
Structure
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