| Reaction Details |
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 | Report a problem with these data |
| Target | Neuromedin-B receptor |
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| Ligand | BDBM50295237 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_577514 (CHEMBL1057866) |
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| IC50 | 370±n/a nM |
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| Citation |  Fu, J; Shuttleworth, SJ; Connors, RV; Chai, A; Coward, P Discovery and optimization of a novel Neuromedin B receptor antagonist. Bioorg Med Chem Lett19:4264-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuromedin-B receptor |
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| Name: | Neuromedin-B receptor |
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| Synonyms: | Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43447.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Bombesin 1 NMBR 0::P28336 |
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| Residue: | 390 |
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| Sequence: | MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLG
NIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIP
VIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAV
FSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLI
KSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSL
GHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAV
RMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
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| BDBM50295237 |
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| n/a |
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| Name | BDBM50295237 |
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| Synonyms: | 11-(2-chloro-6-fluorophenyl)-3,3-dimethyl-8-(trifluoromethyl)-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one | CHEMBL564278 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19ClF4N2O |
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| Mol. Mass. | 438.846 |
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| SMILES | CC1(C)CC(=O)C2C(Nc3cc(ccc3N=C2C1)C(F)(F)F)c1c(F)cccc1Cl |c:16| |
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| Structure | 
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