Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCannabinoid receptor 1/Mu-type opioid receptor
LigandBDBM50295432
Substrate/Competitorn/a
Meas. Tech.ChEMBL_578686
Ki 309±n/a nM
Citation Yang SWHo GTulshian DGreenlee WJAnthes JFernandez XMcLeod RLHey JAXu X Discovery of orally active 3-pyridinyl-tropane as a potent nociceptin receptor agonist for the management of cough. J Med Chem 52:5323-9 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1/Mu-type opioid receptor
Name:Cannabinoid receptor 1/Mu-type opioid receptor
Synonyms:M-OR-1 | MOP | MOR-1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | hMOP | mu-type opioid receptor isoform MOR-1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44789.51
Organism:Homo sapiens (Human)
Description:P35372
Residue:400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50295432
n/a
NameBDBM50295432
Synonyms:2-[exo-8-[Bis(2-chlorophenyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl]-1-piperidineacetonitrile | CHEMBL561115
TypeSmall organic molecule
Emp. Form.C27H31Cl2N3
Mol. Mass.468.461
SMILESClc1ccccc1C(N1[C@H]2CC[C@H]1CC(C2)C1CCCCN1CC#N)c1ccccc1Cl |r,TLB:7:8:14.15.13:10.11,THB:16:14:8:10.11|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: