| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage metalloelastase |
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| Ligand | BDBM28487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_579099 (CHEMBL1062301) |
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| IC50 | 600±n/a nM |
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| Citation |  Li, W; Li, J; Wu, Y; Rancati, F; Vallese, S; Raveglia, L; Wu, J; Hotchandani, R; Fuller, N; Cunningham, K; Morgan, P; Fish, S; Krykbaev, R; Xu, X; Tam, S; Goldman, SJ; Abraham, W; Williams, C; Sypek, J; Mansour, TS Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma. J Med Chem52:5408-19 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage metalloelastase |
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| Name: | Macrophage metalloelastase |
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| Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54012.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P39900 |
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| Residue: | 470 |
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| Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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| BDBM28487 |
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| n/a |
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| Name | BDBM28487 |
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| Synonyms: | (2S)-3-methyl-2-{8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(13),2,4,6,9,11-hexaene-4-sulfonamido}butanoic acid | dibenzofuran (DBF) scaffold, (S)-2b |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17NO5S |
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| Mol. Mass. | 347.386 |
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| SMILES | CC(C)[C@H](NS(=O)(=O)c1ccc2oc3ccccc3c2c1)C(O)=O |r| |
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| Structure | 
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