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TargetMacrophage metalloelastase
LigandBDBM50295492
Substrate/Competitorn/a
Meas. Tech.ChEMBL_579099 (CHEMBL1062301)
IC50 11±n/a nM
Citation Li, WLi, JWu, YRancati, FVallese, SRaveglia, LWu, JHotchandani, RFuller, NCunningham, KMorgan, PFish, SKrykbaev, RXu, XTam, SGoldman, SJAbraham, WWilliams, CSypek, JMansour, TS Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma. J Med Chem52:5408-19 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Macrophage metalloelastase
Name:Macrophage metalloelastase
Synonyms:HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:Enzyme
Mol. Mass.:54012.99
Organism:Homo sapiens (Human)
Description:P39900
Residue:470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50295492
n/a
NameBDBM50295492
Synonyms:(R)-2-(7-(Methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic Acid | CHEMBL550562
TypeSmall organic molecule
Emp. Form.C19H20N2O7S
Mol. Mass.420.436
SMILESCOC(=O)Nc1ccc2c(c1)oc1cc(ccc21)S(=O)(=O)N[C@H](C(C)C)C(O)=O |r|
Structure
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