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TargetMacrophage metalloelastase
LigandBDBM50295511
Substrate/Competitorn/a
Meas. Tech.ChEMBL_579099 (CHEMBL1062301)
IC50 44±n/a nM
Citation Li, WLi, JWu, YRancati, FVallese, SRaveglia, LWu, JHotchandani, RFuller, NCunningham, KMorgan, PFish, SKrykbaev, RXu, XTam, SGoldman, SJAbraham, WWilliams, CSypek, JMansour, TS Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma. J Med Chem52:5408-19 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Macrophage metalloelastase
Name:Macrophage metalloelastase
Synonyms:HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:Enzyme
Mol. Mass.:54012.99
Organism:Homo sapiens (Human)
Description:P39900
Residue:470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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  Blast E-value cutoff:
BDBM50295511
n/a
NameBDBM50295511
Synonyms:(S)-3-Methyl-2-(7-(2-oxooxazolidin-3-yl)dibenzo[b,d]thiophene-3-sulfonamido)butanoic Acid | CHEMBL552313
TypeSmall organic molecule
Emp. Form.C20H20N2O6S2
Mol. Mass.448.513
SMILESCC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)sc1cc(ccc21)N1CCOC1=O)C(O)=O |r|
Structure
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