| Reaction Details |
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 | Report a problem with these data |
| Target | N-formyl peptide receptor 3 |
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| Ligand | BDBM50295513 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_580003 (CHEMBL1051691) |
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| EC50 | 10±n/a nM |
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| Citation |  Cilibrizzi, A; Quinn, MT; Kirpotina, LN; Schepetkin, IA; Holderness, J; Ye, RD; Rabiet, MJ; Biancalani, C; Cesari, N; Graziano, A; Vergelli, C; Pieretti, S; Dal Piaz, V; Giovannoni, MP 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors. J Med Chem52:5044-57 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-formyl peptide receptor 3 |
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| Name: | N-formyl peptide receptor 3 |
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| Synonyms: | FML2_HUMAN | FPR3 | FPR3_HUMAN | FPRH1 | FPRL2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39971.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_580003 |
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| Residue: | 353 |
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| Sequence: | METNFSIPLNETEEVLPEPAGHTVLWIFSLLVHGVTFVFGVLGNGLVIWVAGFRMTRTVN
TICYLNLALADFSFSAILPFRMVSVAMREKWPFGSFLCKLVHVMIDINLFVSVYLITIIA
LDRCICVLHPAWAQNHRTMSLAKRVMTGLWIFTIVLTLPNFIFWTTISTTNGDTYCIFNF
AFWGDTAVERLNVFITMAKVFLILHFIIGFSVPMSIITVCYGIIAAKIHRNHMIKSSRPL
RVFAAVVASFFICWFPYELIGILMAVWLKEMLLNGKYKIILVLINPTSSLAFFNSCLNPI
LYVFMGRNFQERLIRSLPTSLERALTEVPDSAQTSNTDTTSASPPEETELQAM
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| BDBM50295513 |
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| n/a |
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| Name | BDBM50295513 |
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| Synonyms: | (S)-6-amino-2-((S)-2-amino-3-(1H-indol-3-yl)propanamido)-N-((5R,8S,11S,14S)-5-carbamoyl-15-(4-hydroxyphenyl)-8-isopropyl-11-(2-(methylthio)ethyl)-7,10,13-trioxo-2-thia-6,9,12-triazapentadecan-14-yl)hexanamide | CHEMBL552527 |
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| Type | Small organic molecule |
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| Emp. Form. | C41H61N9O7S2 |
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| Mol. Mass. | 856.109 |
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| SMILES | CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(N)=O |r| |
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| Structure | 
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