Reaction Details |
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Target | Prothrombin |
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Ligand | BDBM50295574 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_577598 (CHEMBL1059507) |
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Ki | 2800±n/a nM |
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Citation | Zbinden, KG; Anselm, L; Banner, DW; Benz, J; Blasco, F; Décoret, G; Himber, J; Kuhn, B; Panday, N; Ricklin, F; Risch, P; Schlatter, D; Stahl, M; Thomi, S; Unger, R; Haap, W Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit. Eur J Med Chem44:2787-95 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prothrombin |
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Name: | Prothrombin |
Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
Type: | Protein |
Mol. Mass.: | 70029.57 |
Organism: | Homo sapiens (Human) |
Description: | P00734 |
Residue: | 622 |
Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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BDBM50295574 |
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n/a |
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Name | BDBM50295574 |
Synonyms: | 4-chloro-N-(4-(2-oxo-2-(4-(2-oxo-2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)ethyl)thiazol-2-yl)benzamide | CHEMBL560319 |
Type | Small organic molecule |
Emp. Form. | C22H26ClN5O3S |
Mol. Mass. | 475.992 |
SMILES | Clc1ccc(cc1)C(=O)Nc1nc(CC(=O)N2CCN(CC(=O)N3CCCC3)CC2)cs1 |
Structure |
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