Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM50295596 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_577597 (CHEMBL1059506) |
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Ki | 95±n/a nM |
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Citation | Zbinden, KG; Anselm, L; Banner, DW; Benz, J; Blasco, F; Décoret, G; Himber, J; Kuhn, B; Panday, N; Ricklin, F; Risch, P; Schlatter, D; Stahl, M; Thomi, S; Unger, R; Haap, W Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit. Eur J Med Chem44:2787-95 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50295596 |
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n/a |
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Name | BDBM50295596 |
Synonyms: | 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3R,5S)-1-{[2-FLUORO-4-(2-OXO-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-5-HYDROXYMETHYL-PYRROLIDIN-3-YL)-AMIDE | 5-chloro-N-((3R,5S)-1-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenylamino)-2-oxoethyl)-5-(hydroxymethyl)pyrrolidin-3-yl)thiophene-2-carboxamide | CHEMBL550102 |
Type | Small organic molecule |
Emp. Form. | C23H22ClFN4O4S |
Mol. Mass. | 504.962 |
SMILES | OC[C@@H]1C[C@H](CN1CC(=O)Nc1ccc(cc1F)-n1ccccc1=O)NC(=O)c1ccc(Cl)s1 |r| |
Structure |
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