| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sialidase-2 |
|---|
| Ligand | BDBM4706 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_578459 (CHEMBL1062263) |
|---|
| IC50 | 40000±n/a nM |
|---|
| Citation |  Magesh, S; Savita, V; Moriya, S; Suzuki, T; Miyagi, T; Ishida, H; Kiso, M Human sialidase inhibitors: design, synthesis, and biological evaluation of 4-acetamido-5-acylamido-2-fluoro benzoic acids. Bioorg Med Chem17:4595-603 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sialidase-2 |
|---|
| Name: | Sialidase-2 |
|---|
| Synonyms: | Cytosolic sialidase | N-acetyl-alpha-neuraminidase 2 | NEU2 | NEUR2_HUMAN | Sialidase 2 | Sialidase-2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 42256.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_960638 |
|---|
| Residue: | 380 |
|---|
| Sequence: | MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYD
APTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRAN
VTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLHDRARSLVVPAYA
YRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHL
RARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTH
SWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYE
EIVFLMFTLKQAFPAEYLPQ
|
|
|
|---|
| BDBM4706 |
|---|
| n/a |
|---|
| Name | BDBM4706 |
|---|
| Synonyms: | (2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid | 2,3-didehydro-2-deoxy-N-acetylneuraminic acid | CHEMBL96712 | DANA | Neu5Ac2en |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H17NO8 |
|---|
| Mol. Mass. | 291.2546 |
|---|
| SMILES | CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r,c:7| |
|---|
| Structure | 
|
|---|
Search and Browse
