| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
|---|
| Ligand | BDBM50295875 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_578766 (CHEMBL1052339) |
|---|
| IC50 | 600±n/a nM |
|---|
| Citation |  Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins. Bioorg Med Chem17:4420-4 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
|---|
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
|---|
| Synonyms: | DYR1A_RAT | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | Dyrk | Dyrk1a |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 85573.59 |
|---|
| Organism: | RAT |
|---|
| Description: | Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0 RAT::Q63470 |
|---|
| Residue: | 763 |
|---|
| Sequence: | MHTGGETSACKPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPNISDQQVSALSYSD
QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWSLKKTKDGKREYKPPGT
RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG
HFAAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH
HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS
STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY
QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
|
|
|
|---|
| BDBM50295875 |
|---|
| n/a |
|---|
| Name | BDBM50295875 |
|---|
| Synonyms: | 4-(1H-Indol-3-yl)-5-(3-methoxyphenyl)pyrimidin-2-amine | CHEMBL552407 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H16N4O |
|---|
| Mol. Mass. | 316.3565 |
|---|
| SMILES | COc1cccc(c1)-c1cnc(N)nc1-c1c[nH]c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
